HomeINOMAX DrugDosing, Administration, and Weaning

Dosing, Administration, and Weaning1


  • For term and near-term neonates with hypoxic respiratory failure, the recommended dosing is 20 ppm
  • Doses greater than 20 ppm are not recommended
  • Maintain treatment for up to 14 days, or until underlying oxygen desaturation has resolved and the neonate is ready to be weaned for INOMAX therapy1


  • Users of INOMAX or nitric oxide delivery systems must satisfactorily complete a comprehensive periodic training program provided by the manufacturer
  • INOMAX must be administered using a calibrated INOmax DSIR® Nitric Oxide Delivery System
  • Only validated ventilator systems should be used in conjunction with INOMAX
  • Keep available a backup battery power supply and an independent reserve nitric oxide delivery system
  • Users have access to 24/7/365 customer and technical support provided by Mallinckrodt Pharmaceuticals at 877-566-9466
  • Measure methemglobin within 4 to 8 hours after initiation of treatment with INOMAX and periodically throughout treatment. Monitor for PaO2 and inspired NO2 during INOMAX administration


Abrupt discontinuation of INOMAX may lead to increasing pulmonary artery pressure and worsening oxygenation even in neonates with no apparent response to nitric oxide for inhalation.1
  • To wean INOMAX, down titrate in several steps, pausing several hours at each step to monitor for hypoxemia
  • If desaturation occurs, reinstate INOMAX immediately