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When critical moments arise, INOmax Total Care is there to help support uninterrupted delivery of INOMAX. Watch the stories of a parent and practitioners who appreciate the support INOmax Total Care provides.

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See which common underlying diseases can cause hypoxic respiratory failure (HRF).

INOMAX is an inhaled pulmonary vasodilator that selectively dilates the pulmonary vasculature and improves ventilation and perfusion (V/Q) mismatch.1 Learn how INOMAX can help stop the cascade of hypoxic respiratory failure (HRF) in term and near-term neonates diagnosed with pulmonary hypertension.

Reference: 1. INOMAX. Package insert. Mallinckrodt Pharmaceuticals.

Ventilation and perfusion (V/Q) matching is required for optimal oxygenation of the pulmonary vasculature.1 INOMAX is an inhaled pulmonary vasodilator that can improve V/Q matching.1

See how INOMAX works

Reference: 1. INOMAX. Package insert. Mallinckrodt Pharmaceuticals.

INOMAX has been studied on over 5000 subjects.

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*Primary endpoint of INOMAX CINRGI and NINOS registration studies.

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Recommended dosing, administration, and weaning instructions here.

INOmax DSIR Plus Delivery Systems bring together innovative engineering with an intuitive user experience.1 See the complete array of patient safety features now.

Reference: 1. Data on file. Mallinckrodt Pharmaceuticals

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INOMAX cylinders, calibration gas, and delivery system consumables and accessories are delivered at no additional charge as part of your contract.

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Comprehensive clinician resources are available to you at no extra cost, from device training and technical bulletins to on-demand webinars. Access a variety of support materials and learn more about the resources included in your INOmax Total Care contract.

Access case studies and other supplemental resources on inhaled nitric oxide as treatment for HRF associated with pulmonary hypertension.

Hear highly respected clinicians discuss treatment of neonates with HRF associated with pulmonary hypertension in this INOMAX webinar. Images are used with permissions.

Many organizations are focused on reducing device-related errors and failures. Download information on the latest efforts to improve patient safety.

In addition to on-site training, your INOmax Total Care contract includes access to several online training resources. Access the INOmax DSIR Plus virtual training simulator here.

Have a specific or technical question about an INOmax DSIR Plus Delivery System? Access our complete library of operation manuals, instructional materials, technical bulletins, and safety data sheets.

Find easy-to-understand information about hypoxic respiratory failure (HRF), and answers to some of the most commonly asked questions parents have.

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Home › INOMAX Drug › Dosing, Administration, and Weaning

Dosing, Administration, and Weaning1

Dosing

  • For term and near-term neonates with hypoxic respiratory failure, the recommended dosing is 20 ppm
  • Doses greater than 20 ppm are not recommended
  • Maintain treatment for up to 14 days, or until underlying oxygen desaturation has resolved and the neonate is ready to be weaned for INOMAX therapy1

Administration1

  • INOMAX must be administered using a calibrated FDA-cleared Nitric Oxide Delivery System
  • There are various FDA-cleared Nitric Oxide Delivery Systems (NODS); refer to the NODS labeling to determine which NODS to use with this drug product and for needed information on training and technical support for users of this drug product with the NODS
  • When utilizing the INOmax DSIR® Plus MRI (specifically cleared for use in the MRI suite) only use INOmax MR Conditional cylinders at 100 gauss or less
  • Keep available a backup battery power supply and an independent reserve nitric oxide delivery system
  • Users have access to 24/7/365 customer and technical support provided by Mallinckrodt Pharmaceuticals at 877-566-9466
  • Measure methemoglobin within 4 to 8 hours after initiation of treatment with INOMAX and periodically throughout treatment. Monitor for PaO2 and inspired NO2 during INOMAX administration
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Weaning

Abrupt discontinuation of INOMAX may lead to increasing pulmonary artery pressure and worsening oxygenation even in neonates with no apparent response to nitric oxide for inhalation.1
  • To wean INOMAX, down titrate in several steps, pausing several hours at each step to monitor for hypoxemia
  • If desaturation occurs, reinstate INOMAX immediately