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See which common underlying diseases can cause hypoxic respiratory failure (HRF).

INOMAX is an inhaled pulmonary vasodilator that selectively dilates the pulmonary vasculature and improves ventilation and perfusion (V/Q) mismatch.1 Learn how INOMAX can help stop the cascade of hypoxic respiratory failure (HRF) in term and near-term neonates diagnosed with pulmonary hypertension.

Reference: 1. INOMAX. Package insert. Mallinckrodt Pharmaceuticals.

Ventilation and perfusion (V/Q) matching is required for optimal oxygenation of the pulmonary vasculature.1 INOMAX is an inhaled pulmonary vasodilator that can improve V/Q matching.1

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Reference: 1. INOMAX. Package insert. Mallinckrodt Pharmaceuticals.

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*Primary endpoint of INOMAX CINRGI and NINOS registration studies.

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INOmax DSIR Plus Delivery Systems bring together innovative engineering with an intuitive user experience.1 See the complete array of patient safety features now.

Reference: 1. Data on file. Mallinckrodt Pharmaceuticals

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Home › INOmax Delivery Systems › Alarm Safety & Rebound Pulm HTN

Raise the Alarm

The potential for rebound pulmonary hypertension highlights the importance of monitoring when using vasodilators

It is vital that the delivery devices used in the treatment of pulmonary hypertension help to manage abrupt discontinuation of drug, which may lead to device-related rebound pulmonary hypertension. Abrupt discontinuation of treatment may lead to rebound pulmonary hypertension, a potentially life-threatening condition typically characterized by1:
  • An increase in pulmonary vascular resistance
  • Compromised cardiac output
  • Critical hypoxemia
In patients with severe disease, clinical deterioration can occur rapidly.1

INOmax DSIR® Plus Delivery Systems: alarmed for patient safety

The INOmax DSIR Plus Delivery Systems are designed to deliver the most up-to-date safety features and alarms to help you address many of the complications that can come with treating hypoxic respiratory failure, including the risk of device-related rebound pulmonary hypertension. The alarm features support the National Patient Safety Goal NPSG.06.01.01 on clinical alarm safety for hospitals and critical access hospitals, including2-4:
  • Continuous integrated monitoring with a comprehensive alarm system
  • Audible and visual alarms designed to alert caregivers of potential problems
  • Prioritized alarms (high priority, low priority)
  • Alarm parameters adjustable to actionable levels
In addition to the NPSG requirement, the INOmax DSIR Plus Delivery Systems provide a complete alarm history for record keeping and reporting.1-3

Comparison of delivery system key safety features2-4

INOmax DSIR Plus Delivery Systems are equipped with alarms and backup systems that can alert you to a device delivery problem before a decline in the patient’s condition becomes an “alarm.”
Safety Feature  Feature Description 
INOmax DSIR Plus
INOmax DSIR Plus MRI
Safety Feature Feature Description INOmax DSIR Plus INOmax DSIR Plus MRI
Drug Delivery Failure Alarm Sounds alarm when drug delivery is interrupted (eg, over/under drug delivery)
Backup Delivery Provides backup delivery method that is immediately available for use
Internal Battery Helps maintain uninterrupted power for continuous drug delivery even if main power goes out for up to 6 hours
Backup Drug Supply Helps maintain uninterrupted drug delivery even if main drug supply is depleted
Over-/Underdose Delivery Alarm Sounds alarm if too much or too little drug is being delivered
Drug Concentration Alarm Sounds alarm if incorrect drug concentration is utilized
Sensor Failure Alarm Sounds alarm if monitoring sensors are malfunctioning
Battery Low Alarm Sounds when up to 30 minutes of battery power remains
Auto Purge Automates purge of NO2 from system
Auto Low Calibration Initiates on start-up and at intervals during patient use
GAUSS ALERT™ Dual alarms sound if placed too close to MRI field  
Ergonomic Autobrake Locks cart in place to prevent movement during MRI scans  
Updated Warning Screens Specific to MRI suite use  
MRI Suite-Specific Help Wizard Modified for MRI suite use to stay situationally aware  
Tether Hook Enables use of tether as needed in MRI suite