2023 WINNER - Human Factors and Ergonomics Society, UCD Award

Our next generation of inhaled nitric oxide (iNO) delivery

Our next generation of inhaled nitric oxide (iNO) delivery

You asked. We delivered.

The innovative features of the INOmax EVOLVE™ DS delivery system were guided by input from respiratory therapists and built on a decades-long foundation of partnership.

Weight of the INOmax EVOLVE™ DS device is 26.4 lb, and 29.3 lb with 2 cylinders loaded.1

Streamlined for efficiency with patient safety in mind

The INOmax EVOLVE DS is designed to help reduce device-related workflow. Improved automation adds enhanced safety features to the INOmax® (nitric oxide) gas, for inhalation, delivery system portfolio.1

Uses 1.43-lb, 0.4-L mini-cylinders1,2

Each cylinder weighs 1.43 lb, contains 4,880™ ppm INOmax, and is filled to 3000 psig.

  • Uses 1.43-lb, 0.4-L mini-cylinders1,2
  • Automated cylinder management1
  • Automated pre-use checkout1
  • No high calibrations required1
  • Electronic eINOblender™ backup with automatic activation1

Portable fully integrated system1

The INOmax EVOLVE DS can be removed from the cart. The primary delivery system, monitoring system, 2 cylinder bays, eINOblender™, and additional backup systems are all integrated into a single enclosure.

  • Portable fully integrated system1
  • Touch-screen display with on-screen wizards1
  • EMR connectivity enabled1,3
  • Electronic injector module1,4
If you are interested in learning more about the INOmax EVOLVE DS, contact your representative. Contact a representative

APPLICATIONS

The INOmax EVOLVE DS and DSIR Plus delivery systems deliver INOmax (nitric oxide) gas, for inhalation. These delivery systems must only be used in accordance with the indications, usage, contraindications, and warnings and precautions described in the INOmax package insert and labeling and are indicated for use in term and near term (>34 weeks gestation) neonates with HRF associated with clinical or echocardiographic evidence of pulmonary hypertension. These delivery systems are indicated for a maximum of 14 days of use.

DEVICE WARNINGS

  • Abrupt discontinuation of INOmax can lead to worsening oxygenation and increasing pulmonary artery pressure (rebound pulmonary hypertension syndrome). To avoid abrupt discontinuation, use the EVOLVE DS eINOblender or the DSIR Plus INOblender as a backup immediately to reinstate INOmax therapy and refer to the INOmax package insert.
  • Do not discontinue INOmax delivery if the high NO2 alarm activates. Assess the delivery system for proper setup while maintaining INOmax delivery and verify INOmax and/or FiO2 are appropriate.
  • Do not use equipment that is not specified as part of the systems or that is not designed for INOmax mixtures. Using equipment that is not specified can cause the systems to malfunction.
  • If an alarm occurs, safeguard the patient first before performing troubleshooting procedures.
  • Use only INOmax, pharmaceutical grade NO.

Use in an MR Environment for INOmax DSIR Plus MRI only

Only use a size “88” (1,963 liters) cylinder that is marked “MR Conditional. Keep cylinder at 100 gauss or less.” with the DSIR Plus MRI while in the scanner room. Use of any other cylinder may create a projectile hazard.

  • The INOmax DSIR Plus MRI is classified as MR Conditional with MR scanners of 1.5 or 3.0 Tesla strength ONLY in areas where the field strength is less than 100 gauss.
  • This device contains ferromagnetic components and hence will experience strong attraction close to the magnet. It should be operated at a fringe field of less than 100 gauss.
  • A strong magnetic field such as that from an MRI system can affect the ability of the INOmeter to detect if the cylinder valve is open. This can cause a “Cylinder Valve Closed” alarm to occur when the cylinder valve is actually open. If this alarm occurs, reposition/rotate the INOmax DSIR Plus MRI cart outside the 100 gauss area to reduce the magnetic interference in the area of the INOmeter until the cylinder handle graphic on the display turns green. This will resolve the “Cylinder Valve Closed” alarm. Typically the required INOmax DSIR Plus MRI cart location adjustment is less than 6 inches (15 cm)/90 degrees. Note that interruption of INOmax therapy will occur one hour from point when the “Cylinder Valve Closed” alarm is activated if the alarm is not resolved.

RX ONLY

For the INOmax DSIR Plus consult the Operation Manual which may be found at www.inomax.com/resources, for complete information. For information on the INOmax EVOLVE DS delivery system or for technical assistance for any of these INOmax Delivery Systems, call (877) 566-9466.

References: 1. INOmax EVOLVE™ DS Operation Manual. Madison, WI: Mallinckrodt Pharmaceuticals; 2024. 2. INOmax. Package insert. Mallinckrodt Pharmaceuticals. 3. EVOLVE DS. Serial Data Protocol for versions 01.04.09 and later. Technical Bulletin. TB-23001. Mallinckrodt Pharmaceuticals. 2023. 4. Data on File – Ref-06563. Mallinckrodt Pharmaceuticals.

Live help is available 24/7/365

Call 877-566-9466

Quick Links

INOmax DSIR® Plus Virtual Training Simulator Resource Library FLEXtraNet® Log-in INOmax DSIR® Plus Operation Manual INOmax DSIR® Plus MRI Operation Manual

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APPLICATIONS

  • The INOmax EVOLVE DS and DSIR Plus Delivery Systems deliver INOmax (nitric oxide) gas, for inhalation. The INOmax DSIR Plus Delivery Systems must only be used in accordance with the indications, usage, contraindications, and warnings and precautions described in the INOmax package inserts and labeling. The approved patient population is limited to neonates. Refer to the INOmax Full Prescribing Information prior to use.

APPLICATIONS

The INOmax EVOLVE DS and DSIR Plus delivery systems deliver INOmax (nitric oxide) gas, for inhalation. These delivery systems must only be used in accordance with the indications, usage, contraindications, and warnings and precautions described in the INOmax package insert and labeling and are indicated for use in term and near term (>34 weeks gestation) neonates with HRF associated with clinical or echocardiographic evidence of pulmonary hypertension. These delivery systems are indicated for a maximum of 14 days of use.

DEVICE WARNINGS

  • Abrupt discontinuation of INOmax can lead to worsening oxygenation and increasing pulmonary artery pressure (rebound pulmonary hypertension syndrome). To avoid abrupt discontinuation, use the EVOLVE DS eINOblender or the DSIR Plus INOblender as a backup immediately to reinstate INOmax therapy and refer to the INOmax package insert.
  • Do not discontinue INOmax delivery if the high NO2 alarm activates. Assess the delivery system for proper setup while maintaining INOmax delivery and verify INOmax and/or FiO2 are appropriate.
  • Do not use equipment that is not specified as part of the systems or that is not designed for INOmax mixtures. Using equipment that is not specified can cause the systems to malfunction.
  • If an alarm occurs, safeguard the patient first before performing troubleshooting procedures.
  • Use only INOmax, pharmaceutical grade NO.

Use in an MR Environment for INOmax DSIR Plus MRI only

Only use a size “88” (1,963 liters) cylinder that is marked “MR Conditional. Keep cylinder at 100 gauss or less.” with the DSIR Plus MRI while in the scanner room. Use of any other cylinder may create a projectile hazard.

  • The INOmax DSIR Plus MRI is classified as MR Conditional with MR scanners of 1.5 or 3.0 Tesla strength ONLY in areas where the field strength is less than 100 gauss.
  • This device contains ferromagnetic components and hence will experience strong attraction close to the magnet. It should be operated at a fringe field of less than 100 gauss.
  • A strong magnetic field such as that from an MRI system can affect the ability of the INOmeter to detect if the cylinder valve is open. This can cause a “Cylinder Valve Closed” alarm to occur when the cylinder valve is actually open. If this alarm occurs, reposition/rotate the INOmax DSIR Plus MRI cart outside the 100 gauss area to reduce the magnetic interference in the area of the INOmeter until the cylinder handle graphic on the display turns green. This will resolve the “Cylinder Valve Closed” alarm. Typically the required INOmax DSIR Plus MRI cart location adjustment is less than 6 inches (15 cm)/90 degrees. Note that interruption of INOmax therapy will occur one hour from point when the “Cylinder Valve Closed” alarm is activated if the alarm is not resolved.

RX ONLY

For the INOmax DSIR Plus consult the Operation Manual which may be found at www.inomax.com/resources, for complete information. For information on the INOmax EVOLVE DS delivery system or for technical assistance for any of these INOmax Delivery Systems, call (877) 566-9466.