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When critical moments arise, INOmax Total Care is there to help support uninterrupted delivery of INOMAX. Watch the stories of a parent and practitioners who appreciate the support INOmax Total Care provides.

Learn more about the unmatched offering you receive to help ensure uninterrupted delivery of nitric oxide when you’re contracted with INOmax Total Care.

See which common underlying diseases can cause hypoxic respiratory failure (HRF).

INOMAX is an inhaled pulmonary vasodilator that selectively dilates the pulmonary vasculature and improves ventilation and perfusion (V/Q) mismatch.1 Learn how INOMAX can help stop the cascade of hypoxic respiratory failure (HRF) in term and near-term neonates diagnosed with pulmonary hypertension.

Reference: 1. INOMAX. Package insert. Mallinckrodt Pharmaceuticals.

Ventilation and perfusion (V/Q) matching is required for optimal oxygenation of the pulmonary vasculature.1 INOMAX is an inhaled pulmonary vasodilator that can improve V/Q matching.1

See how INOMAX works

Reference: 1. INOMAX. Package insert. Mallinckrodt Pharmaceuticals.

INOMAX has been studied on over 5000 subjects.

Filter these studies by area of focus:

*Primary endpoint of INOMAX CINRGI and NINOS registration studies.

See more about INOMAX’s safety profile.

Recommended dosing, administration, and weaning instructions here.

INOmax DSIR Plus Delivery Systems bring together innovative engineering with an intuitive user experience.1 See the complete array of patient safety features now.

Reference: 1. Data on file. Mallinckrodt Pharmaceuticals

Compare the different features of INOmax DSIR Plus Delivery Systems.

Review key safety features of the INOmax DSIR Plus Delivery Systems.

Learn more about the innovations that have kept the INOmax delivery systems constantly evolving to meet the ever-changing demands of the critical care space.

INOMAX customers receive 24/7/365 service, education, and technical support. See all the benefits that only come with an INOmax Total Care contract.

INOMAX cylinders, calibration gas, and delivery system consumables and accessories are delivered at no additional charge as part of your contract.

See the complete inventory of INOmax DSIR Plus Delivery System consumables now.

Your INOMAX Critical Care Business Manager and National Account Manager are available to help you navigate the reimbursement process.

Learn more about accessing INOMAX reimbursement support services here.

FLEXtraNet invoicing is designed to help make the invoicing process more transparent and easy. Learn more about the benefits of FLEXtraNet now.

Comprehensive clinician resources are available to you at no extra cost, from device training and technical bulletins to on-demand webinars. Access a variety of support materials and learn more about the resources included in your INOmax Total Care contract.

Access case studies and other supplemental resources on inhaled nitric oxide as treatment for HRF associated with pulmonary hypertension.

Hear highly respected clinicians discuss treatment of neonates with HRF associated with pulmonary hypertension in this INOMAX webinar. Images are used with permissions.

Many organizations are focused on reducing device-related errors and failures. Download information on the latest efforts to improve patient safety.

In addition to on-site training, your INOmax Total Care contract includes access to several online training resources. Access the INOmax DSIR Plus virtual training simulator here.

Have a specific or technical question about an INOmax DSIR Plus Delivery System? Access our complete library of operation manuals, instructional materials, technical bulletins, and safety data sheets.

Find easy-to-understand information about hypoxic respiratory failure (HRF), and answers to some of the most commonly asked questions parents have.

Stay informed on the latest news and information from INOMAX. Register now for email updates.

Have an INOMAX question that needs a quick answer? Get 24/7/365 information support here.

Who’s my local INOMAX representative? Find a complete list of INOMAX representatives by state here.

Find a complete list of INOMAX representatives worldwide here.

As a reminder, this site is intended for US healthcare professionals only.

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Home › INOmax Delivery Systems › INOmax Devices

Alarmed for Your Patients' Most Critical Moments

Focused on safety and innovation in critical care1

INOmax DSIR® Plus Delivery Systems bring together innovative engineering, enhanced user experience, and comprehensive safety features.
  • User-friendly interface1,2
  • Patient safety features and alarms designed to help mitigate and manage the risks of device-related rebound pulmonary hypertension1,2
  • Validated with over 80 ventilators and modes of ventilation1,2*
  • INOmax DSIR Plus Delivery Systems are designed with patient safety in mind1
  • The INOmax DSIR line of delivery systems includes the INOmax DSIR® Plus MRI for use in the MRI suite2
  • INOmax DSIR Plus transport system is designed to effectively transport neonates for seamless delivery of INOMAX therapy1,2
*Contact a sales representative to learn if your ventilator is validated.
See the lineup of INOmax DSIR® Plus Delivery Systems
View delivery systems

Features of the INOmax DSIR® Plus and DSIR® Plus MRI1,2

Virtual Training Simulator

Technical Bulletins

Operations Manual



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Overview Presentation

Technical Bulletins

Operations Manual



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An FDA-cleared delivery system validated for use with multiple ventilation systems

The INOmax DSIR Plus is validated for use with over 80 mechanical and noninvasive ventilation systems:
  • Mechanical ventilation systems, including high-frequency oscillatory and high-frequency jet systems
  • Noninvasive ventilation systems, including CPAP, high-flow nasal cannula, and standard nasal cannula*
INOmax DSIR Plus Delivery Systems are also ISO 13485-validated.
Validated noninvasive ventilation systems*
  • Babi.Plus Bubble PAP Valve and Pressure Relief Manifold
  • Vyaire™ AirLife® nCPAP
  • Fisher & Paykel Healthcare Bubble CPAP
  • Fisher & Paykel Healthcare RT329 Breathing Circuit & BC Nasal Cannula
  • Fisher & Paykel Healthcare RT202 Breathing Circuit & Optiflow™ Adult Interface
  • Hamilton Arabella® Nasal CPAP
  • Standard Neonatal Nasal Cannula
  • Hudson RCI® Neptune® Heated Humidifier With ConchaSmart™ Technology
  • Vapotherm® Precision Flow®
  • Vyaire™ Infant Flow® Nasal CPAP
  • Vyaire™ Infant Flow® SiPAP™
INOMAX is indicated for use in conjunction with ventilatory support and other appropriate agents. Please note that FDA approval of INOMAX was based on clinical studies performed with invasive ventilation only.
For additional information, technical assistance, or a complete list of warnings regarding use of validated ventilators, please refer to the INOmax DSIR Plus Operation Manual at inomax.com/NIVvalidations.
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